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The aim of the study was to investigate the protective effects of Launaea procumbens methanolic extract (LM) against CCl4-induced molecular, hormonal and pathological abnormalities in rats. Male Sprague Dawley rats were provided by National Institute of Health (NIH) Islamabad and orally fed with 100, 200 mg/kg body weight of LM after 48 h of CCl4 treatment (3 ml/kg body weight, 30% in olive oil) biweekly for 4 weeks. The results showed that the administration of LM significantly improved the CCl4-induced serum level of hormones, argyrophilic nucleolar organizer regions (AgNORs) and DNA damages. Histopathology showed that LM reduced the incidence of adrenal lesions induced by CCl4 in rats. These results suggest that LM could protect adrenal against the CCl4-induced oxidative damage in rats.   Key words: Carbon tetrachloride, Launaea procumbens, adrenal histopathology.

Protective effects of Launaea procumbens against oxidative adrenal molecular, hormonal and pathological changes in rats