Exploration of the anti-diabetic effect of the matured seeds of Dioclea reflexa

The study aimed at exploring the anti-diabetic effect of the seed flour of Dioclea reflexa on alloxaninduced diabetic rats. Thirty Wistar rats of both sexes were exposed to respective doses of the seed flour and the standardized drugs (Gliclazide 6.1 mg/kd body weight and Metformin 60 mg/kg body weight) according to the group specifications. The seed flour at a dose of 2 g/kg body weight per oral once daily was found to be more effective than any of the standard drugs with which it was compared. The result showed that D. reflexa seed flour possessed potent oral hypoglycaemic property probably mediated via increased peripheral utilization of glucose.