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This aim of this study was to evaluate the whitening efficacy of the water extract from bamboo shavings (WEBS) in malignant melanoma cells (B-16) of mice. The safety of WEBS was evaluated by the acute oral toxicity test, the repeated skin irritation test and the acute eye irritation test was also evaluated. WEBS showed strong inhibitory effects against the activity of tyrosinase in B-16 cells in a dose dependent manner, and was more potent than arbutin. The melanin content was significantly inhibited by WEBS and the cytotoxicity of WEBS was lower than that of arbutin and hydroquinone. WEBS inhibited mushroom tyrosinase and the maximum was 65.05% at 16 mg/ml with an IC50 of 6 mg/ml. The LD50 was larger than 5000 mg/kg body weight and WEBS was found to be non-toxic and non-irritating.   Key words: Water extract of bamboo shavings, whitening effect, B-16 melanoma cell, safety evaluation.

Evaluation of whitening efficacy and safety of the water extract from bamboo shavings