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A comparison was done for serum lipid profile, glucose, adiponectin and insulin levels with/without hyperlipidemia; and with/without diabetes mellitus-II Wistar rat; with histopathological and immunohistochemical studies on pancreatic Langerhans islets and s-cells (endocrine secretary portion of insulin). Sixty four adult Wistar rats were divided into 8 groups with 14 weeks study duration. The study is an elevation of serum glucose levels and decrease in insulin and adiponectin levels in diabetic groups. Serum lipid profile: triacylglycerol and low density lipoprotein were elevated and high density lipoprotein was decreased in obesity groups. However, these items were in demanded balance after adiponectin treatments. Histopathological alterations were found in diabetic groups severely and moderately in obesity/without diabetes groups. Also, insulin investigation content showed strong immune-reaction in pancreatic β-cells in the control groups and light to null insulin immune-reaction in obesity and diabetic groups when stained with anti-insulin antibody. After adiponectin administration, there was a β-cells dysfunction recovery and moderate insulin immune- reaction.       Key words: Glucose, insulin, adiponectin, diabetes mellitus type-II, pancreatic s-cells

Adiponectin biochemical and histopathological effects on obesity/type-II diabetes mellitus and pancreatic -cell dysfunction in experimental rats