Effect of solvent extracts of Colatropis gigantea leaf on oxidative parameters in diabetic rabbits | Zendy

Emmanuel Nnaemeka Uhuo | Zendy; Victor Nwadiogbu Ogugua | Zendy; N Joshua | Zendy; Elijah Joshua Parker | Zendy

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Effect of solvent extracts of Colatropis gigantea leaf on oxidative parameters in diabetic rabbits

Author(s) -

Emmanuel Nnaemeka Uhuo,

Victor Nwadiogbu Ogugua,

N Joshua,

Elijah Joshua Parker

Publication year - 2015

Publication title -

international journal of medicine and medical sciences

Language(s) - English

Resource type - Journals

ISSN - 2006-9723

DOI - 10.5897/ijmms2015.1139

Subject(s) - tbars , gigantea , antioxidant , catalase , thiobarbituric acid , superoxide dismutase , medicine , vitamin c , glutathione peroxidase , vitamin e , diabetes mellitus , malondialdehyde , biochemistry , lipid peroxidation , chemistry , biology , botany , endocrinology

The effect of Colatropis gigantea leaf extract was studied on alloxan-induced hyperglycaemic rabbits to evaluate the possible hypoglycaemic and antioxidant properties of Colatropis gigantea (C. gigantean) in diabetes mellitus. Significant decrease (p < 0.05) in the thiobarbituric acid reactive substance (TBARS) was observed in diabetic rabbits administered with the acetone fraction of Colatropis gigantea (C. gigantean) leaf when compared to diabetic control group. Consistent significant increases (p < 0.05) were noticed in the activities of erythrocyte antioxidant enzymes; catalase, superoxide dismutase, and glutathione peroxidase in diabetic rabbits treated with acetone fraction of C. gigantea leaf compared with diabetic control group, although higher activities of these enzymes were observed in diabetic rabbits treated with glibenclamide (reference drug) when compared to the group administered C. gigantea extract. It was also observed that C. gigantea extract had significant increase in vitamin C and protein concentrations when compared with untreated group. These results suggest that acetone extract of C. gigantea leaves possess hypoglycaemic and antioxidant properties. Key words: Colatropis gigantean, TBARS, antioxidant enzymes; vitamin C, malondialdehyde (MDA), diabetic rabbits.

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