English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study was made to investigate in-vitro membrane stabilizing, thrombolytic, antioxidant and antimicrobial activities of ethanolic leaf extract of Coccinia indica. Different extractives showed significant membrane stabilizing activity. The ethanol soluble fraction showed (45.36±0.45 % and 64.05±0.22 %) of Red blood cells haemolysis inhibition under heat and hypotonic solution induced conditions, respectively. Mention worthy that carbon tetrachloride soluble fraction of C. indica exhibited highest thrombolytic activity 57.94±0.23% in a comparison with standard streptokinase (SK) (68.89±0.35 %). The antioxidant activities were determined by 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) free radical scavenging. In this case, ethanol soluble fraction (ESF) of crude extract showed fairly significant scavenging (with IC50 value of 2.52 μg/ml) as opposed to a well-known antioxidant, butylated hydroxytoluene (BHT) (IC50 value of 3.99 μg/ml). Pet ether soluble fraction (PESF) and ESF showed mild inhibitory effects against some Gram-positive and Gram-negative bacteria (zone of inhibition was 12 and 13 mm). The overall findings of the studies demonstrated that the leaves of C. indica has fairly significant membrane stabilizing and thrombolytic activity, mild to moderate antioxidant and antimicrobial potential. Thus, may indicated the scientific basis of C. indica leaves as a remedy for traditional uses against fever, pain, oxidative stress, inflammation, infectious diseases, diabetes, etc.   Key words: Coccinia indica, in vitro, thrombolytic, 1,1‐diphenyl‐2‐picrylhydrazyl, antimicrobial activities.

In-vitro membrane stabilizing, thrombolytic, antioxidant and antimicrobial activities of Bangladeshi origin Coccinia indica (Cucurbitaceae)