In vivo antioxidant and lipid peroxidation effect of various extracts from aerial parts of Chomelia asiatica (Linn) in rat fed with high fat diet

The present investigation was to examine the in vivo antioxidant activity and lipid peroxidation activities of different extracts of aerial parts of Chomelia asiatica (Linn). High fat diet rats demonstrated fundamentally decreased the levels of tissues enzymatic antioxidant and non-enzymatic antioxidant (Glutathione). The level of thiobarbuturic acid reactive substance (TBARS) is reduced in high-fat diet (HFD) rats when compared and control group. Administration of ethyl acetate extract of Chomelia asiatica in high fat diet rats were indicated altogether (p<0.001) increased the levels of antioxidant enzymes, for example, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and level of non enzymatic antioxidant glutathione (GSH) when contrasted and HFD rats (Group II). The ethyl acetate extract of C. asiatica in high fat diet rats were discovered lowered the concentration of TBARS when contrasted and HFD rats. In comparison of all the three extracts treated group with standard group, the ethyl acetate extract of C. asiatica showed significant (p<0.001) result than that of other groups. Taking into account the outcomes, we concluded that the ethyl acetate extract of C. asiatica is a significant source of antioxidant, which may be useful in keeping the advancement of different oxidative stresses.