Effect of canagliflozin or metformin on metabolic disorders in obese diabetic rats

This study aimed to investigate the effect of canagliflozin (CAN) or metformin (MET) on investigated biochemical parameters in obese diabetic rat model. Obesity induced by melted butter administration and hyperlipidemic rats were subjected to streptozotocin (STZ; 35 mg/kg i.p) to develop the diabetic model (D). Animals were grouped as control (C), D none treated and diabetic treated with CAN (10 mg/kg) or MET (100 mg/kg) for two and four weeks. Both treated groups showed significant reduction in body weight and CAN group exhibited significant decrease in oral glucose tolerance test (OGTT) as compared to D or MET group in the experimental periods. Both drugs showed hypolipidemic activity by reducing total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) and elevating high-density lipoprotein (HDL) as compared to D group values in the two intervals with advantage in MET effect. Both treatments achieved significant reduction in the diabetic elevated serum values for liver and kidney functions. These results indicate that butter high-fat diet and low dose of STZ makes normal male adult rat associated with hyperlipidemia, glucose intolerance and disturbed liver and kidney functions. Treatment by either CAN or MET resisted the metabolism disturbance of the butter high fat diet/STZ -induced obese type 2 diabetes mellitus rats. Key words: Canagliflozin, metformin, obese diabetic rats, glucose intolerance, biochemical parameters.