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This study aims to investigate the analgesic and anti-inflammatory effects of Commiphora opobalsamum in rodents in comparison with diclofenac, and its ability to enhance the activity of diclofenac in reduced doses. Wister rats or Swiss mice (5 groups/ 6 each) were administered methalonic extract of C. opobalsamum, saline and diclofenac 30 min before the test initiation by i.p. route. The analgesic activities were examined utilizing the acetic acid, hot plate and formalin paw lick techniques. The anti-inflammatory efficacy was examined by utilizing the granuloma induced by cotton pelletand paw edema induced by carrageenan C. opobalsamum demonstrated a stronger inhibition of writhing compared to diclofenac, and the 500 mg/kg dose completely inhibited the writhing response. In hot plate, C. opobalsamum co-administrated with diclofenac exhibited significant prolongation of reaction time compared to diclofenac alone. Furthermore, C. opobalsamum (500 mg/kg) significantly shortens the licking time compared to diclofenac at both phases. In addition, the suppression of paw edema induced by carrageenan was significant in comparison to diclofenac at first hour. Interestingly, significant weight reduction of granuloma tissue was perceived at all doses of C. opobalsamum in contrast to control group. This study provides a strong evidence of the analgesic and anti-inflammatory activity of extract of C. opobalsamum, additionally it has revealed significant anti-inflammatory effect, equivalent to non-steroidal anti-inflammatory drugs (NSAIDs). Moreover, the combination of reduced doses of C. opobalsamum and diclofenac with resultant synergistic potentiation of both analgesic and anti-inflammatory effect, necessitates a cautious approach to elucidate its mechanism with the concomitant meticulous study of its safety profile.

Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents