Design, synthesis and in vitro cytotoxic activity of Delavayin A: A cyclic hexapeptide

Synthesis of new drug for anticancer activity has always been fascinating and interesting for researchers. Increase in the demand for new anticancer agents promotes the researchers for synthesizing new molecules with good activity on human cancer cell lines. Here design, synthesis and cytotoxic, antimicrobial activity of delavayin A is described. The structure of this synthesized compound was confirmed by (IR), 1H NMR, 13C NMR, Mass and elemental analysis. The synthesized compound was evaluated for in vitro cytotoxic activity by using Brine shrimp assay and on PC 3 and HL-60 cancer cell lines at Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Mumbai. The compound was also evaluated for antimicrobial activity by using minimum inhibitory concentration (MIC) technique. The synthesized cyclopeptide possessed moderate cytotoxic activity against cell lines and found to show moderate activity against Gram positive bacteria. Key words: Cyclopeptide, cytotoxic, antimicrobial, p-nitro phenyl ester method.