Evaluation of ethanolic extract of Morinda citrifolia Linn for antitumor activity | Zendy

Cavalcante da Silva Gabriela | Zendy; Cavalcante da Silva Gibbelly | Zendy; Alves Pereira da Silva Waneska | Zendy; Alisson Macário de Oliveira | Zendy; da Silva Mesquita Matheus | Zendy; Concei ccedil Maria | Zendy; Valentim da Silva Evandro | Zendy; Ant ocirc nia de Souza Ivone | Zendy

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Evaluation of ethanolic extract of Morinda citrifolia Linn for antitumor activity

Author(s) -

Cavalcante da Silva Gabriela,

Cavalcante da Silva Gibbelly,

Alves Pereira da Silva Waneska,

Alisson Macário de Oliveira,

da Silva Mesquita Matheus,

Concei ccedil Maria,

Valentim da Silva Evandro,

Ant ocirc nia de Souza Ivone

Publication year - 2016

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp2015.4371

Subject(s) - morinda , sarcoma , in vivo , traditional medicine , pharmacology , chemistry , biology , medicine , microbiology and biotechnology , pathology

Given the concern about to the high incidence of cancer and low specificity of available antineoplasic drugs, Morinda citrifolia Linn is a tropical plant species with wide distribution, which had its consumption widely spread both because it is a source of nutrients and its phytotherapic properties as well as for its adaptation. The potential of tumor inhibition was done in vivo against Ehrlich Carcinoma and Sarcoma 180, a sharp reduction of weight of the tumors was obtained in comparison with the control group. The inhibition of tumor growth compared to Ehrlich carcinoma was more prominent in the dose 200 mg/kg/ip with inhibition percentage of 83.91%, on the other hand against Sarcoma 180. The greatest potential inhibition was detected at the dose of 100 mg/kg/ip with a percentage of 85.86%. Measurements of biochemical and hematological markers did not suffer drastic changes. Thus, the ethanol extract of M. citrifolia Linn showed promising antitumor effects towards the used varieties. Key words: Bioactivity, antitumor, Morinda citrifolia Linn, Sarcoma 180, ehrlich carcinoma.

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