Influence of Chloroform Extract of Sida acuta Burm.f. leaves on the sexual behavior of normal rats

Background: According to traditional ayurvadic book Sida acuta Burm.f. (Malvaceae) claimed to have good aphrodisiac potential but the actual action is not yet proved b y scientific methods. Therefore the present study w as conducted to investigate the aphrodisiac potential of Sida acuta Burm.f. Methods: Acute toxicity test was carried out to determine th nature and extent of untoward reaction which might follow the administration of a single dose (or an o verdose) of a drug. The acute toxicity study was carried out on male mice b y the administration of PE, CH and ME extracts of Sida acuta Burm.f. (Leaves) orally at one dose level (150, 500, 1000, 1500 and 2000 mg/kg) once only. Finally a dose of 2 000 mg/kg was selected which is 1/10 th of the toxic dose. Furthermore male albino rats we re distributed into 5 groups consisting of six rats per group. Rats in group I (control) were administe red with 1 ml/kg, p.o. of saline. Group II rats wer e t eated with Sildenafil citrate at a dose 5 mg/kg, s.c while those in group III, IV and V were given 200 mg/kg of PEE, CE and ME of Sida acuta Burm.f. Sexual behaviour study was carried out on d ays 0, 7, 14, 21 and 28 . Results: The sexual behaviours were preceded with perceptive and pre-copulatory behaviours in th e animals. The increase in Mount Frequency, and Int romission Frequency, and decrease in the Mount and Intromissi on Latencies, Ejaculation Latency and Post Ejaculat ory Phase was observed on 0, 7, 14 and 28 th consecutive days of treatment period. Conclusion: The present investigation reveals that oral administration of all the extracts of Sida acuta Burm.f. leaves showed significant increase in aphrodisiac a ctivity, but CE remarkably enhanced male sexual behavior in male ra ts.