Challenges in research and development of phytomedicines in semisolid pharmaceutical forms

The research and development of new drugs is a slow process that involves costs, requires physical, material and qualified human resources. The purpose of this study was to examine the research of recent years exposed on the challenges and obstacles to production and design of semisolid pharmaceutical forms from extracts or isolated compounds from medicinal plants. This study is an integrative review. The sample consisted of scientific articles found on the databases (Lilacs, Scielo, Science Direct and PubMed) from January 2002 to September 2012. The following descriptors were used: phytomedicines, stability of medicines and pharmaceutical preparations. The design of semisolid pharmaceutical forms, especially those in phytocosmetics, is relevant in Brazil, a major producer country by the pharmaceutical industry. However, due to the peculiarity of each drug and medicine, the study design may become one of the great difficulties of its accomplishment, as well as being a challenge to professionals in developing new pharmaceuticals. Thus, it can be suggested that despite the vast Brazilian biodiversity, there is no investment and cooperation in research and development of new medicines.   Key words: Phytomedicine, drug stability, pharmaceutical preparations.