Antioxidant studies of various solvent fractions and chemical constituents of Potentilla evestita Th. Wolf | Zendy

Abdur Rauf | Zendy

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Antioxidant studies of various solvent fractions and chemical constituents of Potentilla evestita Th. Wolf

Author(s) -

Abdur Rauf

Publication year - 2013

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp2013.3795

Subject(s) - chemistry , antioxidant , dpph , umbelliferone , potentilla , chrysin , chloroform , acacetin , solvent , organic chemistry , traditional medicine , chromatography , flavonoid , apigenin , coumarin , medicine

In the present research work acacetin (1), chrysin (2) and umbelliferone (3) were isolated for the first time from the chloroform fraction of Potentilla evestita. The isolated compounds as well as various solvent fractions of the crude ethanolic extract were assessed for their antioxidant potentials. A significant DPPH free radical scavenging effect was observed in the methanolic and chloroform fractions. The acacetic and chrysin demonstrated significant free radical scavenging activity. Likewise compound 3 showed moderate activity as comparative. It was concluded that the therapeutic potential of this plant is due to its antioxidant potential and the antioxidant effect of P. evestita is due to the presence of these three isolated antioxidant compounds. Key words: Potentilla evestita, acacetin, chrysin, and umbelliferone, antioxidant activity.

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