Evaluation of spermicidal and antiandrogenic activities of aqueous extract of Tinospora cordifolia (Willd.) stem | Zendy

P Ittiavirah | Zendy

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Evaluation of spermicidal and antiandrogenic activities of aqueous extract of Tinospora cordifolia (Willd.) stem

Author(s) -

P Ittiavirah

Publication year - 2013

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp2013.3625

Subject(s) - tinospora cordifolia , epididymis , sperm , male contraceptive , traditional medicine , population , medicine , pharmacology , physiology , chemistry , biology , andrology , environmental health , family planning , research methodology

Control of population is very important in these years. A wide variety of synthetic contraceptive agents are available, but these cannot be used continuously due to their side effects. Thus the present study was undertaken to evaluate the antifertility effect of aqueous extract ofTinospora cordifolia stem studied in male Albino Wistar rats. Male rats were orally administered with aqueous extract of T. cordifolia stem (100 mg/kg of body weight/day, for 60 days) and effect of treatment on reproductive organ weights: fertility potential and sperm count were evaluated. The treatment caused decrease in weight of testis, epididymis and prostate. The treatment caused a significant reduction in average litter size, sperm count, number of viable and motile sperm. The administration of aqueous extract of T. cordifolia led to alteration in both the histoarchitecture of testis and epididymis. The results revealed that the aqueous extract of T. cordifolia stem has spermicidal and antiandrogenic activity. Key words: Tinospora cordifolia, antifertility, antiandrogenic, spermicidal activity

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