Hypolipidemic and antithrombotic evaluation of Myrtus communis L. in cholesterol-fed rabbits

Herbs have been a great source of natural substances used to prevent many cardiovascular diseases (CVD). Blood lipid levels and coagulation parameters are probably the major determinant for producing CVDs. The present study was undertaken to evaluate the hypo-lipidemic and anti-thrombotic activities of aqueous extract of Myrtus communis L. fruit (AEM) in cholesterol-fed rabbits. Hyper-lipidemia was induced following administration of cholesterol for 45 days. Animals of treated group were administered AEM daily for 30 and 45 days at dose of 50 mg/kg. Biochemical tests were performed at the end of dosing that is, on 31st day and again on 46th day. The administration of AEM (50 mg/kg/day) revealed reduction in serum triglycerides and low density lipoprotein; there was also an increase in thrombin and fibrinogen time. Results of present study indicate that the extract exhibited hypolipidemic effects and has also an effect on blood coagulation parameters which may be of value in CVDs. However, further studies are necessary to explore the precise mechanism of action of these effects. Key words: Herbs, lipid profile, blood coagulation, rabbits.