E-Cadherin, beta-catenin and HER2 expression in prostate cancer tissues with perineural invasion and their correlation with Gleason score: A preliminary study | Zendy

Bazan Thomaz Rafael | Zendy; Yabiko Maylla | Zendy; Regina Bonfim Rodrigues Sandra | Zendy; Theodoro Therese | Zendy; Alves Beatriz | Zendy; Ajaime Azzalis Ligia | Zendy; Edimar Cristiano Pereira | Zendy; Berlanga Campos Junqueira Virginia | Zendy; Corazzini Roseli | Zendy; Fernando Adami | Zendy; Luiz Fernando | Zendy

Open Access

E-Cadherin, beta-catenin and HER2 expression in prostate cancer tissues with perineural invasion and their correlation with Gleason score: A preliminary study

Author(s) -

Bazan Thomaz Rafael,

Yabiko Maylla,

Regina Bonfim Rodrigues Sandra,

Theodoro Therese,

Alves Beatriz,

Ajaime Azzalis Ligia,

Edimar Cristiano Pereira,

Berlanga Campos Junqueira Virginia,

Corazzini Roseli,

Fernando Adami,

Luiz Fernando

Publication year - 2014

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp2013.3452

Subject(s) - perineural invasion , prostate cancer , medicine , cancer , oncology , prostate , pca3 , biopsy , pathology

Prostate cancer (PC) is the most common malignant tumor in men. Early identification of prostate cancer may result in improved cure rates and increased life expectancies. Gleason score and clinical range at the time of diagnosis are important factors to predict prognosis and outcome after therapy but additional accurate and reliable biomarkers are warranted. Few biomarkers of prostate cancer have been successfully implemented and used in clinical practice. In this study, we sought to determine the expression of E-cadherin, beta-catenin and human epidermal receptor (HER2) in biopsy specimens of prostate cancer with perineural invasion, and correlate them with Gleason score in order to verify the relationship between those markers and prostate cancer process. Our study demonstrated abnormal expression of E-cadherin, beta-catenin and HER2. On the other hand, our results showed no correlation between Gleason score and the expression of those markers in invasive prostate cancer tissues. Other different biomarkers remain to be identified, that potentially could improve the evaluation of prognostic of the patient. Key words: Biomarkers, biopsy specimens, Gleason score, perineural invasion, prostate cancer.

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