Assessment of Cassia siamea stem bark extracts toxicity and stability in time of aqueous extract analgesic activity | Zendy

Ntandou G F Nsonde | Zendy; D J Bassoueka | Zendy; J.T. Banzouzi | Zendy; Ossibi AW Etou | Zendy; Itou R D G Elion | Zendy; M C Makambila | Zendy; Suzanne Ramos | Zendy; F Benoit Vical | Zendy; A.A. Abena | Zendy; J. M. Ouamba | Zendy

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Assessment of Cassia siamea stem bark extracts toxicity and stability in time of aqueous extract analgesic activity

Author(s) -

Ntandou G F Nsonde,

D J Bassoueka,

J.T. Banzouzi,

Ossibi AW Etou,

Itou R D G Elion,

M C Makambila,

Suzanne Ramos,

F Benoit Vical,

A.A. Abena,

J. M. Ouamba

Publication year - 2015

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp2009.138

Subject(s) - cassia , toxicity , chemistry , analgesic , traditional medicine , petroleum ether , pharmacology , alkaline phosphatase , acute toxicity , bark (sound) , creatinine , biochemistry , medicine , chromatography , biology , extraction (chemistry) , organic chemistry , ecology , alternative medicine , pathology , traditional chinese medicine , enzyme

Cassia siamea Lam (Fabaceae), widely used in tropical countries for its nutritional and pharmacological properties, has been toxicologically evaluated. Oral administration of aqueous (CSE4) and ethanol (CSE3) Cassia siamea stem bark extracts did not show mortality up to 3000 mg/kg in albinos Wistar rats. LD 50 of petroleum ether (CSE1) and dichloromethane (CSE2) extracts were estimated at 1300 and 1275 mg/kg respectively. None of the extracts has cytotoxicity activity on KB and Vero cell lines. There were no differences in body weight and macroscopic examinations. Haematocrit, creatinine, alkaline phosphatase (ALP), alanine amino transferase (ALT) and Asparatate Amino Transferase (AST) parameters did not show difference of levels. Contrariwise, a significant increase in animal weight and blood glucose were observed in animals treated group. This increase can be explained by the presence of polysaccharides and phytosterols (stigmasterol, beta-sitosterol) in this plant. The lyophilised aqueous extract keeps its analgesic property for over two years. Key words: Cassia siamea, stem bark extracts, cytoxicity, subchronic toxicity, pharmacological stability, analgesic activity.

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