A study on the anti-inflammatory effect of aromatic rhinitis spray

The aim of this study was to study the anti-inflammatory effect of a compound containing volatile oils of Flos magnoliae, Centipeda minima and Mentha haplocalyx. The anti-inflammatory effect of the compound was investigated using xylene-, egg white- and cotton pellet-induced inflammation method. The medium- and high-doses of the compound (0.04 and 0.08 ml/kg) significantly inhibited the xylene-induced ear swelling in mice; low-, medium- and high-doses of the compound (0.02, 0.04, and 0.08 ml/kg) all had significant inhibitory effects on degree of paw swelling 30 min after the induction of inflammation; high-dose of the compound (0.08 ml/kg) significantly lowered the weight of cotton pellet granuloma in rats. The compound has a preferable therapeutic effect on both the acute and chronic inflammations, which can be developed as an anti-inflammatory traditional Chinese medicine.