The effect of salidroside on inflammatory factors in rats with hemisection-induced spinal cord injury

The effect of salidroside on inflammatory factors in rats with hemisection-induced spinal cord injury (SCI) was studied. The Sprague-Dawley (SD) rats were divided into six groups: Sham control group, SCI model group, the methylprednisolone sodium succinate (MPSS) treatment group, the salidroside-low dosage treatment group, the salidroside-moderate dosage treatment group and the salidroside-high dosage treatment group. The C2 hemisection method was developed to establish SCI models. 24 h after operation, different dosage of salidroside treatment inhibited some inflammatory factors such as, interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α) and Intercellular adhesion molecule 1 (ICAM-1). These results suggested that salidroside can significantly inhibit the increased inflammatory factors in acute SCI.   Key words: Salidroside, spinal cord injury (SCI), inflammatory factors.