Detection, biological effectiveness, and characterization of nanosilver-epidermal growth factor sustained-release carrier | Zendy

Huiqing Xie | Zendy

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Detection, biological effectiveness, and characterization of nanosilver-epidermal growth factor sustained-release carrier

Author(s) -

Huiqing Xie

Publication year - 2013

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp12.1470

Subject(s) - epidermal growth factor , growth factor , cell growth , bacterial growth , materials science , transmission electron microscopy , wound healing , chemistry , nanotechnology , medicine , bacteria , biology , biochemistry , immunology , receptor , genetics

A nanosilver-epidermal growth factor sustained-release carrier was synthesized with the self-assembly method and characterized by transmission electron microscopy and Ultra violet (UV) spectrophotometry. The biological activity of the sustained release carrier was determined through cytological, bacteriological, and wound-healing experiments. The results show that the nanosilver-epidermal growth factor sustained-release carrier was well dispersed, with uniform particle size and that it had good antibacterial properties that were similar to those of nanosilver. Nanosilver-epidermal growth factor sustained-release carrier is superior to epidermal growth factors in effectively promoting cell division and proliferation. The results of wound-healing experiments show a curative effect. Key words: Epidermal growth factor, nanosilver, antibacterial, wound, cell proliferation.

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