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The effect of salidroside (SD) on learning and memory ability of vascular dementia (VaD) rats were studied. The Wistar rats were randomly divided into six groups: Sham-operation group, VaD group, positive control (PC) group, SD high dose (SD-HD) treatment group, SD moderate dose (SD-MD) treatment group and SD low dose (SD-LD) treatment group. The bilateral common carotid arteries of Wistar rats were permanently ligated to established VaD models. The special study and memory were observed by Y-maze test. At postoperative 4, 8 and 12 weeks, error number (EN) and total reaction time (TRT) in the VaD, PC, SD-HD, SD-MD and SD-LD group were significantly more than those in the sham- operation group (P 0.05). These results suggested that SD could improve the learning and memory ability of VaD rats by different dosages.       Key words: Salidroside, vascular dementia, rats.

Effect of salidroside on learning and memory ability of vascular dementia rats