Evaluation of hydro-alcoholic extract of leaves of Boerhaavia diffusa for anxiolytic activity in rats | Zendy

Kumar Malik | Zendy

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Evaluation of hydro-alcoholic extract of leaves of Boerhaavia diffusa for anxiolytic activity in rats

Author(s) -

Kumar Malik

Publication year - 2013

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp11.660

Subject(s) - anxiolytic , haloperidol , diazepam , elevated plus maze , pharmacology , chemistry , ketamine , catalepsy , medicine , anesthesia , anxiety , psychiatry , biochemistry , receptor , dopamine

The hydro-alcoholic extract of Boerhaavia diffusa of leaves was investigated for evaluation of exhibited anxiolytic activity in rats at a dose 100 and 200 mg/kg by p.o. route for elevated plus maze test, hole-board test, haloperidol induced catalepsy and ketamine induced sleep method. Results of in vivo activity lead to the conclusion that the hydro-alcoholic of B. diffusashowed predominantly significant activity which is compared to the standard drug, diazepam (0.5 mg/kg). Key words: Boerhaavia diffusa, anxiolytic activity, diazepam, haloperidol, hydro-alcoholic extract, ketamine, sleep.

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