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Three analogues of formamidine disulphide (FMD) were synthesized as potential integrase inhibitor of human immunodeficiency virus (HIV). Piperonal, 3-Nitrobenz-aldehdye and 3,4,5-trimethoxybenzaldehyde, were respectively coupled with formamidine disulphide to prepare piperoformamidine disulphide (P-FMD), 3-Nitro-formamidine disulphide (N-FMD) and 3,4,5-trimethoxyformamidine disulphide (T-FMD). The structures of the three products were confirmed with infrared (IR), nuclear magnetic resonance (NMR) and mass spectrometry(MS) spectroscopic techniques, as reported.       Key words: Human immunodeficiency virus (HIV), acquired immune deficiency syndrome (AIDS), formamidine disulphide (FMD).

Synthesis of three formamidine disulphide derivatives as potential integrase inhibitors of human immunodeficiency virus (HIV)