Synthesis of three formamidine disulphide derivatives as potential integrase inhibitors of human immunodeficiency virus (HIV)

Three analogues of formamidine disulphide (FMD) were synthesized as potential integrase inhibitor of human immunodeficiency virus (HIV). Piperonal, 3-Nitrobenz-aldehdye and 3,4,5-trimethoxybenzaldehyde, were respectively coupled with formamidine disulphide to prepare piperoformamidine disulphide (P-FMD), 3-Nitro-formamidine disulphide (N-FMD) and 3,4,5-trimethoxyformamidine disulphide (T-FMD). The structures of the three products were confirmed with infrared (IR), nuclear magnetic resonance (NMR) and mass spectrometry(MS) spectroscopic techniques, as reported.   Key words: Human immunodeficiency virus (HIV), acquired immune deficiency syndrome (AIDS), formamidine disulphide (FMD).