Seeking colorectal carcinoma related genes based on regulation network | Zendy

Tiejian Yang | Zendy

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Seeking colorectal carcinoma related genes based on regulation network

Author(s) -

Tiejian Yang

Publication year - 2011

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp11.223

Subject(s) - transcriptome , colorectal cancer , gene , microarray , gene ontology , computational biology , gene regulatory network , biology , bioinformatics , gene expression , genetics , cancer

Colorectal carcinoma (CRC) is one of the most frequent cancers worldwide with very high mortality. In this study, the microarray data was used to construct a regulation network to identify potential genes related with CRC. The results showed SP1, RELA, STAT1, PPARA and TP53 arise as hub nodes in transcriptome network in accordance with previous studies, and new transcription factors and target genes related with CRC were also identified, such as HIF1A and NFIC both regulated the PFKFB3 in response to CRC. In general, it is demonstrated that transcriptome network analysis is useful in identification of CRC related genes. Key words: Colorectal carcinoma, network, ontology.

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