Apoptosis induced in human breast cancer cell line by Acanthaster planci starfish extract compared to tamoxifen | Zendy

Faisal Mutee | Zendy

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Apoptosis induced in human breast cancer cell line by Acanthaster planci starfish extract compared to tamoxifen

Author(s) -

Faisal Mutee

Publication year - 2012

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp11.208

Subject(s) - starfish , acanthaster , tamoxifen , apoptosis , breast cancer , mcf 7 , cancer research , cytotoxic t cell , cytotoxicity , annexin , medicine , pharmacology , cancer , cancer cell , chemistry , oncology , biology , human breast , in vitro , biochemistry , ecology , great barrier reef , fishery , coral reef

Breast cancer remains the most common cancer among women all over the world. Current chemotherapeutic drugs for breast cancer such as tamoxifen show severe side effects. Therefore, there is a focus toward new chemotherapeutic agents to be obtained from natural sources. This study was carried out to evaluate cytotoxic and apoptotic effects of the Acanthaster planci starfish extract compared to tamoxifen in human breast cancer MCF-7 cell line. The extract was obtained using phosphate buffered saline. MTS assay and Annexin V assay were performed to evaluate the cytotoxic effect and apoptotic effect, respectively. The extract was found to inhibit the growth of MCF-7 cells (IC

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