Pharmacological studies of some pyrimidino derivatives

Pyrimidine derivatives, in general, have received significant interest due to their purported biological activities the anti-inflammatory, analgesic, anti-Parkinsonism, and anti-microbial activities for five 2[(Nmethyl indolyl)-methyl] pyrimidino derivatives 1-5 is reported. Pharmacological screenings showed that these compounds have good anti-inflammatory, analgesic, anti-Parkinsonism, and anti-microbial activities comparable with reference drugs. Compound 2 showed similar activity of diclofenac sodium as analgesic. Compound 1, 2, 4 and flurbiprofen exhibited essentially equipotent anti-inflammatory activities. Compounds 1 and 3 were the most potent anti-Parkinsonism agents compared with benztropine. In addition, compounds 1-5 showed antimicrobial activities comparable to streptomycin, erythromycin and fusidic acid as reference drugs. These pharmacological studies provide the activities for new pyrimidino derivatives and are expected to possess notable chemical and pharmacological activities for further pharmacological research.