Evaluation of anti-tumor activity of water-soluble polysaccharides from Dendrobium denneanum | Zendy

Yijun Fan | Zendy

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Evaluation of anti-tumor activity of water-soluble polysaccharides from Dendrobium denneanum

Author(s) -

Yijun Fan

Publication year - 2011

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp11.089

Subject(s) - polysaccharide , chemistry , sephadex , dendrobium , size exclusion chromatography , chromatography , ethanol precipitation , aqueous solution , extraction (chemistry) , cellulose , biochemistry , botany , biology , organic chemistry , enzyme

Three water-soluble polysaccharides (DDP1-1, DDP2-1 and DDP3-1) were obtained from the aqueous extracts of the stems of Dendrobium denneanum by hot water extraction, ethanol precipitation, and fractionated by DEAE-cellulose ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The main structure characterizations and anti-tumor activities of three fractions were evaluated in this paper. The results showed DDP1-1 with 12.50 mg/kg could significant inhibit the increment of the tumor, increase immune index of S180 mice, and also strongly promote the secretion of IL-2, TNF-α and IFN-γ. Therefore, results of these studies demonstrated the polysaccharide DDP1-1 has strong anti-tumor and immunomodulation abilities. Key words: Immunomodulating, Dendrobium denneanum, polysaccharide, anti-tumor.

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