Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients | Zendy

Hassan Ahmadv | Zendy

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Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Author(s) -

Hassan Ahmadv

Publication year - 2011

Publication title -

african journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

ISSN - 1996-0816

DOI - 10.5897/ajpp11.018

Subject(s) - acne , isotretinoin , triglyceride , medicine , antioxidant , lipid profile , gamma glutamyltransferase , vitamin e , oxidative stress , cholesterol , gastroenterology , chemistry , dermatology , enzyme , biochemistry

The aim of the present study was the evaluation of serum level of lipids and gamma glutamyl transpeptidase (GGT) activities in patients with acne vulgaris undergoing isotretinoin treatment. Forty-four patients, with severe acne or moderate acne (age mean 23.6±6.0 year) who were resistant to conventional treatment were supplemented with 0.5 mg/kg/day of oral isotretinoin for 120 days. This study revealed a significant increase in serum level of cholesterol, triglyceride and GGT activity. The findings of this work showed a number of negative effects of isotretinoin on disturbances in lipid profile and antioxidant status, in acne patients. Therefore, to control abnormalities in lipid profiles and oxidative stress, we recommend further studies to use antioxidant such as vitamin E supplementation in patients using isotertinoin. Key words: Acne vulgaris, isotertinoin, serum lipid, gamma glutamyl transpeptidase (GGT).

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