English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Paracetamol (PAR) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of “Paracetamol for direct compression” are present on the market. Current research demonstrated the best tablet properties with coated paracetamol (mass of tablets, diameter, height and mechanical strength, friability RSD<2%). Furthermore, coated paracetamol in combination with both investigated superdisintegrants such as Vivasol®and Polyplasdone® XL-10 shows faster disintegration time and dissolution rate in comparison to paracetamol for direct compression. Eventually, the major advantages of the formulation with coated paracetamol for industrial production are decrease of friability and superiority in terms of flowability, compressibility, quick disintegration and dissolution. Regarding the results, coating of PAR particles is beneficial for the manufacturing of tablets with immediate release.       Key words: Paracetamol, powder, direct compression, immediate release, superdisintegrants.

Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression