Dissolution rate enhancement of bicalutamide by adsorption process

The aim of the present research was to enhance the dissolution rate of poorly water soluble drug, bicalutamide by adsorption process. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carrier like povidone K30 and adsorbent like magnesium aluminum silicate were used as dissolution rate enhancers. Granules of bicalutamide were prepared by wet granulation technique by using magnesium aluminum silicate and povidone K 30 either alone or in combination at different concentrations. The granules were evaluated for packing and compression properties. The granules were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.   Key words: Bicalutamide, magnesium aluminum silicate, adsorption, povidone K 30.