Open AccessSubstituent effects of 2-aryl-trans-decahydroquinolin-4-ones in CTADC oxidation: Spectrophotometric approach
Author(s) -
N. Sharmila,
R. Sambasiva Rao,
Babu B Hari,
Golakoti Trimurtulu,
P. V. V. Satyanarayana
Publication year - 2014
Publication title -
african journal of pure and applied chemistry
Language(s) - English
Resource type - Journals
ISSN - 1996-0840
DOI - 10.5897/ajpac2014.0555
Subject(s) - chemistry , substituent , aryl , kinetics , acetic acid , catalysis , solvent , medicinal chemistry , high performance liquid chromatography , redox , organic chemistry , nuclear chemistry , alkyl , physics , quantum mechanics
A kinetic study was carried out using spectrophotometric approach on the oxidation of nine differently substituted 2-aryl-trans-decahydroquinolin-4-ones by Cetyltrimethylammonium dichromate (CTADC) as oxidant at 30°C and in aqueous acetic acid (50%) containing catalytic amount of sulphuric acid (6N). The reactions were studied at 350 nm. The reaction was found to follow second order kinetics. The substitution of methyl group at position three of the decahydroquinoline ring and the presence of electron releasing groups in the aryl group increased the rate of oxidation of the substrates. The change in the rate of oxidation with temperature and solvent composition was also studied. The products formed during the oxidation were also confirmed by using high-performance liquid chromatography (HPLC) and spectral analysis. Key words: 2-aryl-trans-decahydroquinolin-4-ones, kinetics, oxidation, Cetyltrimethylammonium dichromate (CTADC).
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