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A growth inhibition effect against four Gram-negative (Pseudomonas aeruginosa, Salmonella typhimurium, Klebsiella pneumoniae and Escherichia coli) and three Gram-positive (Staphylococcus aureus, Bacillus cereus and Enterococcus faecalis) pathogenic bacteria was observed for 19 of 20 tested synthetic compounds (that is seven -aminoethers, nine -aminoalcohols and four allylamines). According to the results, the Gram-negative bacteria were the most susceptible strains toward the tested compounds. In general, the MICs of the active compounds were around 1000 ppm, while the MBCs were around 2000 ppm; however, the allylamine 8a was highlighted for its ability to inhibit E. faecalis at the lowest concentration found in this study (MIC = 125 ppm and MBC = 250 ppm).   Key words: Antibacterial activity, -aminoether derivatives, minimal inhibitory concentration, minimal bactericidal concentration, Lipinski’s rule.

Antibacterial in vitro assays of new -aminoethers and derivatives against Gram-negative and Gram-positive pathogenic bacteria