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Enterobacter cloacae is not a primary human pathogen but has obtained an important role as a nosocomial pathogen. Acquiring this property of metallo-β-lactamases (MBL) producers, the pathogen becomes very virulent for the susceptible neonates and leaves little choice of antibiotics for its management. Blood samples (n=103) were collected in peadriatic blood culture bottles from suspected neonates aseptically. The samples were processed in BACTEC 9120. Antimicrobial susceptibility testing was performed using Kirby-Bauer disc diffusion method according to CLSI 2009. Carbapenems resistant E. cloacae were further analyzed for the detection of carbapenamase as per CLSI guidelines and MBL production by double disc potentiation method. Of 103 blood cultures specimens, 71 were declared positive by BACTEC 9120 and 91 isolates were recovered. Among these isolates, E. cloacae (n=12) were found to be carbapenems resistant and 10 out of these were carbapenamase and MBL producers. All MBL producing pathogens were pan-drug resistant. The spread of MBL among E. cloacae is an emerging threat particularly in hospitalized neonates.   Key words: Enterobacter cloacae, metallo-β-lactamases (MBL), antimicrobial resistance.

Metallo--lactamase producing Enterobacter cloacae: An emerging threat in neonates