Genetic diversity of bovine viral diarrhoea virus in Beijing region, China from 2009 to 2010

The genetic diversity of bovine viral diarrhea viruses (BVDV) from Beijing region, China between 2009-2010, was investigated using a phylogenetic analysis of partial 5’untranslated region (5’UTR) nucleotide sequences from 61 BVDV positive samples, and for 13 selected samples, the N pro region was also investigated. All the sixty-one blood samples were collected from cattle that were BVDV persistently infected (PI) within a BVD eradication program on Beijing farms during 2009 and 2010. Phylogenetic analysis based on 5’UTR sequences indicated that all BVDV positive samples were of the BVDV-1 genotype, but were clustered into four different subtypes: sub-genotype 1b (n = 31), 1m (n = 24), 1c (n = 4) and 1d (n = 2). BVDV-1b and 1 m are the most prevalent sub-genotypes in Beijing. The results also demonstrate that in most herds, certain BVDV-1 sub-genotype predominates. It is the first time that BVDV-1d is reported in China with unclear origin. The result of this study will be useful in constructing an effective vaccination plan to further control BVDV in Beijing region.