Expression of haptoglobin in Trichosporon asahii induced skin infection and its immunoregulatory role in mice | Zendy

Ao Jun Hong | Zendy; Hao Feng | Zendy; Yong Liao | Zendy; He Zhu | Zendy; Yang Rong Ya | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Expression of haptoglobin in Trichosporon asahii induced skin infection and its immunoregulatory role in mice

Author(s) -

Ao Jun Hong,

Hao Feng,

Yong Liao,

He Zhu,

Yang Rong Ya

Publication year - 2013

Publication title -

african journal of microbiology research

Language(s) - English

Resource type - Journals

ISSN - 1996-0808

DOI - 10.5897/ajmr12.482

Subject(s) - haptoglobin , immunosuppression , immune system , gene expression , microarray , biology , immunology , microbiology and biotechnology , gene , biochemistry

7cfu/ml T. asahii suspension. 0.5, 1, 3 and 5 d after inoculation, mice was sacrificed and skin lesion was collected. mRNA expression of Hp gene was detected by RT-PCR. Microarray was employed to investigate immune related gene expression profile. In both groups, mRNA expression of Hp was detected as 0.5, 1, 3 and 5 d after T. asahii infection, but the Hp expression in IS group was significantly higher than that in non-IS group (P<0.01). One day after T. asahii infection, Hp expression was significantly higher than that of 0.5, 3 and 5 d after infection (P<0.01). A total of 11 immune related differentially expressed genes were identified in the microarray assay and the gene encoding Hp protein was up-regulated. Hp involves in the T. asahii infection of skin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research