Immunogenicity of a tuberculosis DNA vaccine expressing a fusion protein Ag85B - MPB64 in mice | Zendy

Meng Xianying | Zendy; Lin Shan | Zendy; Qiang Zhang | Zendy; Li Qu | Zendy; Jie Li | Zendy

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Immunogenicity of a tuberculosis DNA vaccine expressing a fusion protein Ag85B - MPB64 in mice

Author(s) -

Meng Xianying,

Lin Shan,

Qiang Zhang,

Li Qu,

Jie Li

Publication year - 2012

Publication title -

african journal of microbiology research

Language(s) - English

Resource type - Journals

ISSN - 1996-0808

DOI - 10.5897/ajmr12.1952

Subject(s) - immunogenicity , dna vaccination , mycobacterium tuberculosis , tuberculosis vaccines , vaccination , mycobacterium bovis , virology , tuberculosis , immune system , microbiology and biotechnology , bcg vaccine , immunology , medicine , biology , immunization , pathology

++ cells, and induced significantly higher levels of cell-mediated immune responses, as compared with vaccination with PBS or the pVAX1 empty vector. High levels of antibodies observed in the sera of immunized mice depicted strong humoral responses generated by DNA vaccine constructs. All the experimental vaccines imparted significant protection against challenge with M. tuberculosis H37Rv as compared to vector controls. These results show that the newly developed pMB vaccine may be used for the prevention and therapeutic intervention of MTb infection.

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