Genetic variation analysis of hemagglutinin and neuraminidase of human influenza A/H3N2 virus in Hong Kong (1997-2006) | Zendy

Shubo Zhang | Zendy; Yue Chen Jake | Zendy; Rao Jianan | Zendy; Shanghong Zhang | Zendy; Wai Tin Chan Daniel | Zendy; Guanghua Liu | Zendy; Yang Xu | Zendy; Miao He | Zendy

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Genetic variation analysis of hemagglutinin and neuraminidase of human influenza A/H3N2 virus in Hong Kong (1997-2006)

Author(s) -

Shubo Zhang,

Yue Chen Jake,

Rao Jianan,

Shanghong Zhang,

Wai Tin Chan Daniel,

Guanghua Liu,

Yang Xu,

Miao He

Publication year - 2014

Publication title -

african journal of microbiology research

Language(s) - English

Resource type - Journals

ISSN - 1996-0808

DOI - 10.5897/ajmr12.128

Subject(s) - neuraminidase , hemagglutinin (influenza) , virology , h5n1 genetic structure , virus , biology , antigenic drift , phylogenetic tree , antigenic shift , amino acid , glycosylation , influenza a virus , mutation , genetics , gene , covid-19 , medicine , infectious disease (medical specialty) , disease , pathology

We analyzed the phylogeny, amino acid variations, positive selection, and glycosylation patterns of hemagglutinin (HA) and neuraminidase (NA) of A/H3N2 in Hong Kong from 1997 to 2006. The results suggest that continuity and latency of influenza viruses might be the reasons why different influenza viruses co-circulate within the same season. Many amino acid mutations were retained for two or more successive years. The preferred antigenic sites of mutation are sites A and B in HAs, and site B in NAs. An influenza pandemic may be caused by higher-than-threshold level of amino acid variations of the virus. Key words: Influenza virus, A/H3N2, phylogenetic analysis, selection pressure, N-glycosylation.

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