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The antimicrobial activity of the peptide K9CATH against Mycobacterium tuberculosis H37Rv in vitro and its therapeutic potential against pulmonary tuberculosis in a murine model was evaluated. By the alamar blue colorimetric assay, a minimum inhibitory concentration (MIC) of 10.66 μg/ml was obtained. Also, K9CATH did not show to be cytotoxic at 32 μg/ml on lung cells (A549). Electron microscopy images obtained of M. tuberculosis treated with the peptide showed disruption of the membrane and condensation of the cytoplasmic content. Mice infected with M. tuberculosis H37Rv and treated with 32 μg/ml of K9CATH for 30 and 60 days showed a significant decrease (p < 0.5) in colony-forming units (CFU) and pneumonic area.

Evaluation of the K9CATH peptide in the treatment of experimental pulmonary tuberculosis