Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts | Zendy

Tatjana Kundaković | Zendy; Milenković Marina | Zendy; Aleks | Zendy; Aleksandra Topić | Zendy; Tatjana Stanojković | Zendy; Juranić Zorica | Zendy; Lakuscaron ić Branislava | Zendy

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Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts

Author(s) -

Tatjana Kundaković,

Milenković Marina,

Aleks,

Aleksandra Topić,

Tatjana Stanojković,

Juranić Zorica,

Lakuscaron ić Branislava

Publication year - 2011

Publication title -

african journal of microbiology research

Language(s) - English

Resource type - Journals

ISSN - 1996-0808

DOI - 10.5897/ajmr11.453

Subject(s) - cytotoxicity , antimicrobial , micrococcus luteus , enterococcus faecalis , chemistry , candida albicans , traditional medicine , antibacterial activity , microbiology and biotechnology , escherichia coli , bacteria , medicine , biology , in vitro , biochemistry , organic chemistry , genetics , gene

Cytotoxicity and antimicrobial activity of cyclohexane, dichlormethane and methanol extracts of Teucrium scordium subspec. scordioides was studied. Cyclohexane and dichlormethane extracts of T. scordium possessed high citotoxicity against MDA-MB-361 cells (IC50=130.33±0.1 μg/ml and IC50=189.89±3.99 μg/ml, respectively). Dichlormethane extract was more effective against MDA-MB-453 cell line (IC50=130.33 ± 0.1 μg/ml). The methanol extract of T. scordium possessed no cytotoxicity against breast cancer cell lines, MDA-MB-361 and MDA-MB-453. Herb extracts of T. scordium have shown weak antibacterial activity on Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Bacillus subtilis with no activity against Staphylococcus aureus, S. epidermidis,Micrococcus luteus, Enterococcus faecalis, and Candida albicans. Key words: Teucrium scordium subsp. scordioides, cytotoxicity, antimicrobial activity.

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