MPB64 DNA vaccine with immunogenicity and efficacy against tuberculosis | Zendy

Yao Yunyi | Zendy; Hou Qian | Zendy; Hua Jin | Zendy; Lin San | Zendy; Yajun Wang | Zendy; Xue Jian-hong | Zendy; Li Sun | Zendy; Hong Huarong | Zendy; Xiaoli Zhou | Zendy; Fang Chen | Zendy

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MPB64 DNA vaccine with immunogenicity and efficacy against tuberculosis

Author(s) -

Yao Yunyi,

Hou Qian,

Hua Jin,

Lin San,

Yajun Wang,

Xue Jian-hong,

Li Sun,

Hong Huarong,

Xiaoli Zhou,

Fang Chen

Publication year - 2012

Publication title -

african journal of microbiology research

Language(s) - English

Resource type - Journals

ISSN - 1996-0808

DOI - 10.5897/ajmr11.1306

Subject(s) - immunogenicity , dna vaccination , virology , mycobacterium tuberculosis , tuberculosis , tuberculosis vaccines , microbiology and biotechnology , vaccination , infectious disease (medical specialty) , plasmid , dna , medicine , biology , immunology , antibody , disease , pathology , genetics

Tuberculosis is a serious infectious disease caused by Mycobacterium tuberculosis. DNA vaccination is an advanced technique for protecting human bodies from infectious diseases including tuberculosis by injecting exogenous gene engineering DNA into the body to produce an immunological response. In this study, we examined the immunogenicity and protective efficacy of DNA vaccine (pCDNA-MPB64) expressing MPB64 protein and its booster effects in mice for controlling tuberculosis. The results showed that MPB64 DNA vaccine led to a dramatic augmentation of humoral and cellular responses. All these suggested that MPB64 DNA vaccines is an ideal vaccine and may be further developed as a useful method to prevent tuberculosis. Key words: Tuberculosis, DNA vaccines, MPB64, recombination plasmid, antibody titer.

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