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A total of 550 subjects from the community and 190 subjects from health care-related facilities in Riyadh, Saudi Arabia were evaluated for the prevalence of nasalStaphylococcus aureus colonization and to identify risk factors associated with S. aureusand methicillin-resistant S. aureus (MRSA) colonization. Among the community subjects,1% had nasal MRSA colonization. Subjects from health care-related facilities had a lowerS. aureus colonization rate (4.2%) than community subjects (1.2%), but had a significantly higher rate of colonization with MRSA (1.65%). Age (P < 0.001) was a significant risk factor for S. aureus colonization, with subjects under age 21 years or between 52 and 61 years showing higher rates of colonization. Recent gastrointestinal disease (P = 0.010) and hospital admission (P = 0.011) were risk factors for nasal MRSA colonization. Comparison of hospital MRSA isolates with the colonization strains by staphylococcal cassette chromosome mec (SCCmec) gene typing and pulsed-field gel electrophoresis (PFGE) typing revealed that, most MRSA strains carried in the community were SCCmec type IV and that most clinical hospital isolates were type III, while health care facility-related carriage isolates were mainly SCCmec type III and type IV. Two new variant SCCmectypes were identified. Six clusters of PFGE patterns were distinguished: two mainly comprised health care facility-related MRSA strains, three mainly comprised community MRSA strains and one comprised mixed community and health care facility-related MRSA strains. In conclusion, a high prevalence of MRSA colonization was observed among people with no relationship to the hospital setting. The high level of multiple-drug resistance among community MRSA strains in association with the previously reported excessive use of antibiotics highlights the importance of the problem of antibiotic selective pressure. Our results indicate that, both the colonial spread of MRSA and the transmission of hospital isolates contribute to the high MRSA in the community.       Key words: Staphylococcus aureus, methicillin-resistance, molecular subtyping.

Molecular subtyping of multiresistant community-associated methicillin-resistant Staphylococcus aureus isolates in Riyadh, Saudi Arabia