English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Larrea divaricata Cav. is a plant used in Argentinean folk medicine. The aim of this work was to evaluate the effect of a purified fraction (F1) obtained from an extract of the plant on murine macrophages (MO) against a systemic infection by Candida albicans. Mice were divided in four groups: 1) healthy without treatment; 2) healthy with F1 treatment; 3) infected, without treatment; and 4) infected with F1 treatment. Peritoneal MO were harvested and the following tests were performed: Apoptosis, phagocytosis, hydrogen peroxide (H2O2) production, nitric oxide (NO) production, determination of seric TNF- aand IL-10 and toxicity of F1. Results showed that F1 increased phagocytosis, H2O2production, superoxide anion and NO levels in presence of C. albicans. These effects are probably due to a modulate mechanism of diverse receptors, such as TLR-2, Dectin-1, mannose receptor and CRs. Apoptosis and TNF-a levels were also increased by F1. The use of this fraction did not induce toxicity on mice. In conclusion, F1 induces a state of pre- activation of MOs, which is enhanced by the presence of C. albicans. The lack of toxicity in addition with the immunomodulatory action becomes F1 a potential safe treatment of disseminated candidiasis.       Key words: Larrea divaricata, fraction, macrophages, disseminated candidiasis, immunomodulatory activity.

Larrea divaricata Cav. enhances the innate immune response during the systemic infection by Candida albicans