English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The benefit of exploration and exploitation of crude oil to the Nigerian economy is not without its negative consequences. Apart from the indirect exposure to crude oil due to spillage, the consumption of this crude oil by the rural populace living in oil rich regions as traditional medicine for illnesses have evoked local and international concerns. The aim of this study was to investigate the histological and biochemical disrupting effects of Escravos crude on the liver and heart in Chinchilla rabbits. A total of thirty Chinchilla rabbits aged twelve to fourteen weeks and weighing 1.2 to 1.45 kg were used. Crude oil was orally given at the doses of 15, 20, 25 and 30 mg/kg body weight, corresponding to groups B, C, D and E, respectively for 28 days while group A (control) received distilled water. The result show a dose dependent significant increase in the serum concentrations of total cholesterol, creatine kinase, Creactive protein, alanine transaminase and aspartate transaminase (p<0.05). The histological findings include: lymphocytic infiltration, cirrhosis, fibrosis, hemosiderin, oedema, mild tissue scaring and tissue necrosis. Thus, this result suggests that Escravos crude oil is a potential biochemical disruptor and can also affect the micro-architecture of liver and heart. Key words : Escravos crude oil, liver, heart, biochemical parameters, histology, Chinchilla rabbits.

Histopathological and biochemical disrupting effects of Escravos crude oil on the liver and heart in Chinchilla rabbits