A STUDY OF ULCER INDUCED STOMACH OF ALBINO RATS TREATED WITH IDOGU MIXTURE, A POTENT ANTI-ULCER HERBAL DRUG

Aim: The aim of this study was to assess the potency of the anti-ulcer drug, Idogun on the stomach of ulcer induced albino rats. Method: Six groups of locally bred albino rats were used. Each group containing five rats of either sex were orally treated respectively with distilled water (ulcer control group), omeprazole 20mg/kg (reference group) and 100, 200, 400 and 800mg/kg extract of Idogun anti –ulcer mixture (experimental group). Rats were sacrificed one hour after oral administration of 1ml absolute ethanol to induce injury in the gastric mucosa. Results: Tissue sections from ulcer induced rats contained haemorrhage, dense infiltration by mixed inflammatory cells and extensive ulceration. These features were absent in the ulcer induced rats that were subsequently treated with the Idogun mixture. Mild tissue edema and presence of inflammatory cells were observed in the omeprazole treated section. Conclusion: Idogun anti-ulcer herbal mixture is a potent anti-ulcer drug. Key words: Idogun mixture, Stomach ulcer, Herbal