Evaluation of serum proteins in some immunocompromised patients in Auchi, Edo State, Nigeria | Zendy

GRA Okogun | Zendy; DJ Jemikalajah | Zendy; ME Adu | Zendy; R. S. Saliu | Zendy

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Evaluation of serum proteins in some immunocompromised patients in Auchi, Edo State, Nigeria

Author(s) -

GRA Okogun,

DJ Jemikalajah,

ME Adu,

R. S. Saliu

Publication year - 2015

Publication title -

african journal of cellular pathology

Language(s) - English

Resource type - Journals

eISSN - 2636-672X

pISSN - 2449-0776

DOI - 10.5897/ajcpath15.012

Subject(s) - medicine , globulin , albumin , immunology , serum albumin , tuberculosis , pregnancy , blood proteins , antibody , immune status , immune system , beta globulins , gamma globulin , human immunodeficiency virus (hiv) , physiology , biology , pathology , genetics

Aim: Immuno compromised state is a condition of alteration in the immune status of an individual, thereby promoting progression of a disease. This work investigated serum proteins in immuno compromised individuals. Methods: 5ml venous blood was collected from 120 volunteers which comprised 20 tuberculosis patients, 40 Human immunodeficiency virus patients, 40 pregnant women and 20 age –sex matched apparently healthy individual as controls in Central Hospital Auchi, Edo State. Standard colorimetric method was used to determine the serum total protein, albumin, and globulin as well as albumin/globulin ratio. Results: A significant increase in total proteins, albumin, and globulins as well as albumin/globulin ratio of Tuberculosis and HIV patients but decrease in pregnant women when compared with control subjects was observed. Conclusion: Serum protein is a significant diagnostic index in the management of immune-compromised patients. Keywords: Immuno-compromised, HIV, Tuberculosis, Pregnancy

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