The effect of oral administration of the mixture of honey and garcinia kola on the kidney of wistar rats

Aim: Honey and Garcinia kola have long been used separately by the traditional medical practitioners as remedies for cough and other ailments. Recently, a combination of both as a remedy for cough is common. This work was intended to see the effect of this synergy on the kidney. Methods: Twenty five Wistar albino rats weighing 180±10g were grouped into 5 (A, B, C, D, E) of 5 rats each. They were fed twice daily for 14 days with a mixture of G. kola and honey: 0.16g/kg + 0.5ml, 0.20g/kg + 0.5ml, 0.24g/kg + 0.5ml, 0.28g/kg + 0.5ml and normal feeds respectively. The rats were sacrificed on the 15th day and blood and kidneys were taken for biochemistry and histology respectively. Results: Sodium, potassium, chloride, bicarbonate, urea, creatinine, as well as the histology of the kidney of the test rats were not significantly different from the control rats. Conclusion: Oral intake of one nut Garcinia kola along with about 5 ml honey  twice daily for 14 days has no adverse effect on the kidney. Key words: Honey, Garcinia kola, Liver, Medicinal plant