Myracrondruon urundeuva Allemo: Chemical composition, antioxidant activity, antimicrobial activity and inotropic effect | Zendy

Luiz Lima Menezes Santos Andre | Zendy; Davi Prado Lima Jose | Zendy; Rolemberg Andrade Clívia | Zendy; Maria Santos Deisylaine | Zendy; Santos Dias Antonio | Zendy; A Pietra | Zendy; Karolina Vianunes Rafaela | Zendy; Evaldo Rodrigues Menezes Filho Jose | Zendy; Nilson Andrade Santos Jose | Zendy; Maria Lins Vasconcellos Carla | Zendy; Yu Kwan Shan Andrea | Zendy; Brancilene Santos de Araújo | Zendy; Santos Estevam Charles | Zendy

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Myracrondruon urundeuva Allemo: Chemical composition, antioxidant activity, antimicrobial activity and inotropic effect

Author(s) -

Luiz Lima Menezes Santos Andre,

Davi Prado Lima Jose,

Rolemberg Andrade Clívia,

Maria Santos Deisylaine,

Santos Dias Antonio,

A Pietra,

Karolina Vianunes Rafaela,

Evaldo Rodrigues Menezes Filho Jose,

Nilson Andrade Santos Jose,

Maria Lins Vasconcellos Carla,

Yu Kwan Shan Andrea,

Brancilene Santos de Araújo,

Santos Estevam Charles

Publication year - 2017

Publication title -

african journal of biotechnology

Language(s) - English

Resource type - Journals

ISSN - 1684-5315

DOI - 10.5897/ajb2017.15892

Subject(s) - phytochemical , antimicrobial , dpph , chemistry , traditional medicine , terpene , tbars , enterococcus faecalis , ethyl acetate , proteus mirabilis , antioxidant , food science , chromatography , biochemistry , lipid peroxidation , medicine , escherichia coli , organic chemistry , gene

Caatinga biome features species with high therapeutic potential such as Aroeira do Sertao (Myracrodruon urundeuva Allemao) which has long history in folk medicine. This study aimed to chemically characterize the secondary metabolites of hydroethanolic extract and hexane, chloroform, acetate, hydroethanolic fractions from Myracrodruon urundeuva (Allemao) possibly responsible antioxidant and antimicrobial activity, besides to evaluate the inotropic effect of crude extract in the left atrium of Cavia porcellus. Phytochemical composition was evaluated by spectrophotometry and high-performance liquid chromatography (HPLC). Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hidrazyl (DPPH•) scavenging and reactive substances to thiobarbituric acid methods. Inotropic effect was evaluated using the isolated organ model. Data were expressed as mean ± SEM and differences determined by ANOVA followed by Tukey test. Phytochemical screening and the HPLC confirmed the presence of flavonoids, terpenes, tannins. Acetate and Hydroethanolic extract showed inhibition of DPPH values of 81.56 and 93.28% respectively. On the other hand, TBARS reduced in extract were 64.13% in a concentration of 150 µg/mL. Hydroethanolic extract and acetate fraction with concentrations of 50 and 100 mg/mL showed inhibition zones between 11.00 and 20.50 mm suggesting antimicrobial activity against Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae bacteria and Candida albicans. The isolated atrium model demonstrated that the extract acts non-competitively antagonizing muscle calcium currents, decreasing the force of contraction by about 60%. Flavonoids, terpenes and tannins are responsible for M. urundeuva (Allemao) biological effects. Key words: Myracrondruon urundeuva, chemical composition, antioxidant activity, antimicrobial activity, inotropic effect.

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