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Today, there are sufficient validated scientific data that support the existence of relations between diabetes and certain neuropsychiatric disorders, such as behavioral disorders, anxiety, cognitive decline and depression. The objective of this work was to investigate the effect of a natural bioflavonoid, the antioxidant hesperidin on the neuro behavioral alterations and locomotor function in streptozotocine diabetic wistar rats. Twenty eight male rats were divided equally into four groups; control, and treated series (hesperidin, streptozotocine and hesperidin+ streptozotocine) then exposed to open field test, where animals were individually placed in the center of the compartment for a period of 5 min. Results of the open field test showed high level of anxiety and a slowdown in locomotion and mental flexibility on diabetic rats. Treatment with hesperidin, significantly module these disorders of the animals related to diabetes. Thus, our results confirm the capacity of hesperidin as an antioxidant, to correct neurobehavioral and locomotion disorders related to diabetes and its complications by neutralizing free radicals generated by this metabolic disease. Key words: Diabetes, oxidative stress, hesperidin, streptozotocine.

Hesperidin effects on behavior and locomotor activity of diabetic Wistar rat