Genetic determinants of antifungal resistance in Candida species | Zendy

Danielly Beraldo dos Santos Silva | Zendy; Barufatti Grisolia Alexéia | Zendy; Mari Pires de Oliveira Kelly | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genetic determinants of antifungal resistance in Candida species

Author(s) -

Danielly Beraldo dos Santos Silva,

Barufatti Grisolia Alexéia,

Mari Pires de Oliveira Kelly

Publication year - 2016

Publication title -

african journal of biotechnology

Language(s) - English

Resource type - Journals

ISSN - 1684-5315

DOI - 10.5897/ajb2016.15295

Subject(s) - antifungal , biology , antifungal drugs , point mutation , drug resistance , resistance (ecology) , antifungal drug , genetics , genome , microbiology and biotechnology , mutation , gene , ecology

In the previous decades, it has been an increase in cases of resistance to antifungal agents used in the prophylaxis and treatment of infections caused by Candida species. The emergence of resistance to drug classes, it is usually explained by genome alterations ranging from point mutations to gain or loss of whole chromosomes. Therefore, identify and understand into the molecular mechanisms that underlie resistance of the Candida spp. is important because this information can provide appropriate treatments in emergency candidemia cases. In this sense, this review have the aim of discuss about the genetic variations associated the antifungal resistance in Candida spp. Key words: Antifungal agents, candidiasis, molecular characterization, mutations, overexpression.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research